Poliarterite nodosa due to anti elastase antibody

Poliarterite nodosa due to anti elastase antibody

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The Authors related one case of polyarteritis nodosa Wellington Socks occurred to a men forty eight years old.The clinical was characterized by mesenteric and femoral arteries occlusion and chronic cutaneous ulcers to legs.There were bioptical aspects of systemic vasculitis with necrotizing inflammation and a paucity of immune deposit.

It was effective oral cyclophosphamide plus steroids.This disease was closely associated with antibodies anti elastase (HLE).The patient had not a history of copyright abuse or LES disease but the nucleolar pattern ANA was positive >1:640 (anti-nDNA negative).

Similar case ANA positive associated with the anti-elastase antibodies, was described by Nassberger (Lancet 1989) for 6/104 Boys Jackets patients with LES, anti-nDNA negative.The patient with the highest anti-elastase concentration subsequentely died after very rapid development of severe brain and kidney involvement.